這個基因編碼一個RNA結合蛋白TET家族的成員所編碼的蛋白質作為一個多亞單位轉錄起始因子tfiid復合物的不同亞組分在rna聚合酶ii基因轉錄中發揮作用。涉及該基因的易位在急性白血病和骨外黏液樣軟骨肉瘤中起作用，該基因突變可能在肌萎縮性側索硬化中起作用。另外，已經觀察到該基因編碼多個亞型的剪接轉錄變體。
This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.