Current data indicates that nuclear pore complex (NPC) RanBP2 (SUMO E3 ligase) protein sumoylates Mdm2 and HDAC proteins during nuclear translocation. A sumoylation-deficient HDAC showed reduced deacetylation activity and suggests that sumoylation may be an important regulatory mechanism for the control of transcriptional repression.
Contributor: Roger Anderson, PhD
REFERENCES: Kirsh O et al. The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J. 2002 Jun 3;21(11):2682-91 Kuersten S et al. Nucleocytoplasmic transport: Ran, beta and beyond. Trends Cell Biol. 2001 Dec;11(12):497-503. Review. Miyauchi Y et al. Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes. J Biol Chem. 2002 Dec 20;277(51):50131-6.