這個基因編碼的蛋白質是一種I型膜蛋白，形成α和β干擾素受體的兩條鏈之一。受體的結合和激活刺激Janus蛋白激酶，進而磷酸化一些蛋白質，包括STAT1和STAT2編碼的蛋白質也作為抗病毒因子發揮作用[由RefSeq提供，2008年7月]
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]