這個基因編碼的蛋白質類似于ERM（Ezrin，radixin，moesin）蛋白質家族的一些成員，這些成員被認為將細胞骨架成分與細胞膜中的蛋白質聯系在一起。該基因產物與細胞表面蛋白、參與細胞骨架動力學的蛋白以及參與調節離子轉運的蛋白相互作用。該基因在胚胎發育過程中高水平表達；在成人中，在雪旺細胞、腦膜細胞、晶狀體和神經中有顯著表達。該基因突變與Ⅱ型神經纖維瘤病有關，Ⅱ型神經纖維瘤病以神經系統、皮膚腫瘤和眼部異常為特征。兩個主要亞型和一些次要亞型是通過選擇性剪接轉錄產生的。
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.