這個基因是一組基因的一員，在緊張的生長停滯狀態和用DNA破壞劑治療后，這些基因的轉錄水平會增加。無論p53的狀態如何，電離輻射對該基因的誘導都發生在某些細胞系中，其蛋白反應與電離輻射后細胞凋亡有關。
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.